Journal: Antibiotics
Article Title: Imidazoles and Quaternary Ammonium Compounds as Effective Therapies against (Multidrug-Resistant) Bacterial Wound Infections
doi: 10.3390/antibiotics13100949
Figure Lengend Snippet: Overview of average MIC values of S. aureus SH1000 and S. epidermidis CL7 of the checkerboard analyses (MICO = miconazole with BENZETH = benzethonium chloride ( n = 3), CETRI = cetrimonium chloride ( n = 3), BENZALK = benzalkonium chloride ( n = 5 for SH1000, n = 3 for CL7), OCT = octenidine dihydrochloride ( n = 3)) after 24 h of incubation. The cumulative fractional inhibitory concentration index (Σ FIC) was calculated based on the MICs of both components in monotherapy and combination therapy. At FIC ≤ 0.5, combinations are considered as synergistic (indicated in green) with the average FICI depicted in the table.
Article Snippet: Similarly, stocks (100×) of benzalkonium chloride (Sigma-Aldrich, 12060), benzethonium chloride (TCI Europe NV, B0044) and cetrimonium chloride (hexadecyltrimethylammonium chloride, Thermo Scientific Chemicals, Waltham, MA, USA, 10762402) were dissolved in dH 2 O at a concentration of 20 mM.
Techniques: Incubation, Concentration Assay